Jesper Tegnér | Professor,Entrepreneur, Consult, and fashion victim
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RECENT NEWS> Tegnér repesents the CompMed Team at the "Systems Biology meets the Clinic" - The second Bertinoro workshop on Systems Biology April 13-18. 2008. The Tegnér-Björkegren laboratory hosts "seminars in systems medicine" and a resource page for systems medicine. 25 January 2008 There are now open positions in the Tegnér-Björkegren laboratory. 15 January 2008 Fredrik Edin defends his PhD thesis at KTH. 11 January 2008 Congratulations - Roland Nilsson PhD, now a postdoc fellow at the Broad Institute, Department of Systems Biology, Harvard University, received a 5 year postdoctoral scholarship from the Knut and Alice Wallenberg Foundation, December 2007 The CompMed team received strong external grant support from VR (1 junior research position and 3 project grants) and VINNOVA (1 senior research position including a project grant). November 2007 Major medical paper [paper 56] on CRP protein and its role in Atherosclerosis. [press release] August, 2007 Clinical Gene Network participates in the third Swedish-American Life Science Summit, June, 2007 Clinical Gene Network lecture on systems biology tools for drug development Pharmaceutical Meeting, Copenhagen, June, 2007 Lecturing at the first workshop on Clinical Systems Biology, Italy, May 2007 Roland Nilsson defends his PhD thesis. May 2007 Clinical Gene Network lecture on systems biology tools for drug development April, 2007 Major mathematical paper [paper 49] in Journal of Machine Learning Research (highest ranked journal in computer science) on feature selection. The proofs for algorithms are relevant for a wide range of problems in medicine. February2007 Lecturing at the Winter School on systems biology. Puerto de la Cruz, Tenerife, Canary Islands, February 2007 Two reviews in Journal of Lipid Research and Trends in Genetics [papers 44 & 43] on networks in aherosclerosis and computational algorithms for identifying networks. January 2007 Our paper on reconstruction on the macrophage LPS gene network [paper 34] has been one of the most downloaded papers at Science Direct. January 2007 Added an internal lab web page (passwd protected) and updated the publication list. January 2007 Lecturing at the 2nd workshop on systems neurobiology. International school for advanced studies (SISSA), Trieste, Italy December 2006 Popular Science lecture at Gentekniknämnden (Systems Biology, October, 2006 Popular science article on systems biology and our work in the magazine Naturvetaren, September, 2006 We organize a national PhD course on Systems Biology Oct-Nov 2006. Julian Macoveanu defends his PhD thesis at Karolinska Institutet. September 2006 |
Welcome to the world of Jesper Tegnér
| [site updated March, 4, 2008] |
Value statement: Welcome to my world. I am designed as such because I believe in exploring the boundaries of what we are. I´m interested in developing and applying operational mathematical strategies which have relevance to the fundamental principles of living matter, not yet captured by theoretical physics. This perspective is transformed into an active research program targeting cardiovascular systems medicine, network biology, computational biology and entrepreneurship within the BioIT sector. Popular description in swedish here.About me: I´m multilingual Chaired Professor In Computational Biology since February 2002, having three different undergraduate degrees (Mathematics, Medicine, Philosophy), a parallell 2 year track of PhD courses in Pure and Applied Mathematics, in addition to another PhD/MD in Computational and Experimental Medicine at Karolinska Institutet, 1997. I was an Alfred P Sloan and Wenner-Gren 5 year Fellow during my research in Boston, USA (1998-2001).Community building: I serve as an associate editor for the journals BMC Systems Biology, BMC Research Notes and on the Editorial Board for IET Systems Biology. I have been active in arranging a number of international conferences and workshops since returning from USA. Upcoming events include serving in the program committe for International Conference on Systems Biology 2008 and organizing an ESF sponsored exploratory workshop om modeling complex diseases (Barcelona, Spain, September 2008). For the local community the Tegnér-Björkegren laboratory has recently (2008) launched "Seminars in Systems Medicine" and a systems medicine resource page (check our labpage)Teaching: I also teach and develop courses on systems and computational biology with a medical focus. The most recent one (2006) was the highly popular national PhD course on Systems Biology - from model organisms to complex diseases. To stimulate the public interest for Mathematics, Natural Sciences and Medicine I give popular science lectures.Grants: We gratefully acknowledge the generous external support that the Tegnér-Björkegren laboratory (external CompMed labpage, research description) has attracted since 2002. This includes national funding agencies such as VR (3 junior research positions, several project grants), SSF, Vinnova (one senior research position, several project grants), Wenner-Gren Foundation, Heart-Lung Foundation, KK-stiftelsen (FMB, 3 PhD positions), ALF (Stockholm County), international collaborative grants Japan-Sweden (Vinnova), EU (PROCARDIS IP, FP6 and VPH NoE FP7), NSF (USA-Sweden), Australian Research Council (Australia - Sweden-Japan), European Science Foundation (Spain-Sweden) and industrial support from biotech/pharmaceutical companies Astra-Zeneca, Pfizer, Affymetrix, VinnNU, and Clinical Gene Networks.Publications: The CompMed Team has published 64 papers (check our labpage). Below (Left) you find a list of 10 selected Mathematical/Computational papers since 2005 published in computational/theory journals. To the Right 10 selected Medical publications are listed. These are published in more traditional biomedical journals where the notion of impact is more relevant compared to computational journals. Average impact for the ten biomedical papers is 11.3. |
10 Selected Mathematical/Computational Papers since 2005 |
10 Selected Medical Papers since 2002 | |
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[Paper - 59] Deconstructing the core dynamics from complex regulatory biological circuit IET Systems Biology [To appear][Paper - 52] Electrotonic Signals Along Intracellular Membranes May Interconnect Dendritic Spines and Nucleus., PLoS Computational Biology [To appear][Paper - 49] Consistent feature selection for pattern recognition in polynomial time, Journal of Machine Learning Research, 8 (March): 589-612, 2007 [pdf][Paper - 48] Detecting Multivariate Differentially Expressed Genes, BMC Bioinformatics, 8 :150 doi 10.1186/1471-2105-8-150 2007 [pdf] [Supp1] [Supp2] [Supp3][Paper - 40] Towards scalable and Data Efficient Learning of Markov Boundaries, International Journal of Approximate Reasoning, 45(2), 211-232, 2007. [pdf here] [Paper - 37] Evaluating Feature Selection for SVMs in High Dimensions. Lecture Notes in Computer Science,719-726, Springer, 2006 [pdf here] [Paper - 31] Detection of compound mode of action by computational integration of whole-genome measurements and genetic perturbations, BMC Bioinformatics 7 :51 doi 10.1186/1471-2105-7-51 2006 7:51. [pdf here][Paper - 30] A flexible implementation for support vector machines. The Mathematica Journal, Vol 10, 114-127, 2005 [pdf here] [Paper - 29] Scalable, Efficient and Correct Learning of Markov Boundaries under the Faithfulness Assumption. Lecture Notes in Computer Science, Symbolic and Quantitative Approaches to Reasoning with Uncertainty 3571, 136-147, 2005 [pdf here][Paper - 24] Growing Bayesian Network Models of Gene Networks from Seed Genes. Bioinformatics, 21, ii224-ii229, 2005 [pdf ] |
[Paper - 61] Transcriptional Profiling Uncovers a Network of Cholesterol-Responsive Atherosclerosis Target Genes PLoS Genetics [To appear][Paper - 56] Human C-reactive protein slows atherosclerosis development in a mouse model with human-like hypercholesterolemia. Proceedings of National Academy of Science Aug, 2007 [pdf] [Supp1] [Supp2][Paper - 43] Perturbations to uncover gene networks. Trends in Genetics,Jan;23(1):34-41, 2007 [pdf] [Paper - 42] Stronger synaptic connectivity as a mechanism behind development of working memory-related brain activity during childhood. Journal of Cognitive Neuroscience, May;19(5):750-60, 2007 [pdf here][Paper - 39] Development of Brain Activity Related to Working Memory and Distraction. Cerebral Cortex May; 17: 1047-1054, 2007 [pdf here][Paper - 28] The transcriptional landscape of the mammalian genome, Science. Sep 2;309 (5740):1559-63, 2005 [pdf][Paper - 16] Division of labor among distinct subtypes of inhibitory neurons in a cortical microcircuit of working memory. Proceedings of National Academy of Science101:1368-1373, 2004 [pdf][Paper -14] Systembiology is taking off. Genome Research. Nov;13(11):2377-80. 2003 [pdf here] [Paper - 9] Reverse engineering gene networks -- integrating genetic perturbations with dynamical modeling. Proceedings of National Academy of Science. 100, 5944-5949, 2003 [pdf] [Paper - 6] Reverse engineering gene networks - singular value decomposition and robust regression. Proceedings of National Academy of Science, 99: 6163-6168. 2002 [pdf]
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